Associate Director Biochemistry and Biophysics

Company: American Society for Biochemistry and Molecular Bi
Location: Lexington
Posted on: February 23, 2021

Job Description:

American Society for Biochemistry and Molecular Biology

• Associate Director Biochemistry and Biophysics Associate Director Biochemistry and Biophysics Associate Director, Biochemistry and Biophysics The ideal candidate will provide experienced leadership in overseeing the development and implementation of biochemical and biophysical assays for hit screening and lead optimization and will collaborate cross-functionally to support drug discovery efforts across the portfolio. This individual will be an expert in enzymology and have a broad understanding of current assay technologies, instrumentation, and screening formats required to identify and characterize small molecule inhibitors of enzymes and protein-protein interactions. Candidates experienced in DNA damage response biology and with experience successfully managing external service providers will be prioritized. Job Responsibilities:
  • Lead a team of scientists in the design, development, validation, and implementation of a broad range of biochemical assays for small molecule screens against novel targets in DNA damage response pathways
  • Establish and manage collaborations with external CROs performing assay development and miniaturization, assay transfer, library screening, hit validation, and biophysical characterization of lead compounds across projects
  • Oversee protein production and purification to support biochemical and biophysical assay development
  • Develop expert knowledge of biochemical mechanisms of program targets and DDR biology and serve on cross-functional project teams as the biochemistry expert
  • Lead productive discussions on key scientific and strategic issues with internal and external colleagues at all levels of the organization
  • Stay current with new technologies and relevant scientific advances in biochemical techniques and assay formats from literature, scientific meetings, and professional network
  • Review and ensure the quality of scientific data to meet regulatory expectations and author technical and regulatory documents to support advancement of therapeutics to clinical testing
  • Act in accordance with all Cyteir Therapeutics policies and be a positive contributor to company culture Requirements Job Qualifications:
    • PhD and 8+ combined years of postdoctoral research experience and/or industry experience developing and implementing biochemical and biophysical assays to support drug discovery
    • Expertise in the areas of enzymology, enzyme kinetics and current assay formats for several enzyme classes and protein-protein-interaction targets and experience with high-throughput screening and hit validation
    • Hands-on experience performing biophysical techniques such as SPR, ITC, and DSF
    • Experience with mass spectrometry, proteomics, and protein crystallography will be prioritized
    • General knowledge of early drug discovery process and demonstrated leadership on cross-functional teams
    • Demonstrated success using in-house and external resources to advance programs from assay development to drug candidate characterization
    • Well organized and able to maintain detailed records of experimental work
    • Ability to communicate clearly and decisively in an open, timely manner
    • Demonstrated ability to effectively train, manage, and mentor junior scientists
    • A sense of adventure and excitement to help build a successful biotech company and work in a highly dynamic research environment Job Information
      • Job ID: 55875856
      • Location:
        Lexington, Massachusetts, United States
      • Position Title: Associate Director Biochemistry and Biophysics Precision targeting of key DNA repair mechanisms is the key to synthetic lethal therapies for cancer and autoimmune disease. In contrast to other therapies which completely eliminate the target's activity (e.g. kinase inhibitors), the key to targeting DNA repair is to partially reduce or precisely alter the activity of specific DNA repair factors. In this way, target cells with genetically defined gain-of-function abnormalities will self-destruct without harming healthy tissues. This works because cells with certain gain-of... Research Associate Translational Research Lexington, Massachusetts, United States 3 days ago Senior/Principal Scientist - Discovery Biology Senior Research Associate, Biochemistry &... LifeMine Therapeutics Cambridge, Massachusetts, United States QU Quinnipiac University QU Quinnipiac University EM Scientist II, AAV External Analytical Development... 11200 Rockville Pike, Suite 302Rockville, Maryland 20852(240) 283-6590

Keywords: American Society for Biochemistry and Molecular Bi, Huntsville , Associate Director Biochemistry and Biophysics, Executive , Lexington, Alabama